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Med-Tech Blog
Movie and Real Life
Submitted by thanhtran on 9 December, 2005 - 9:33pm. Med-Tech BlogThis entry is in relation to Science Makes Sex Obsolete and will fulfill my 500 word entry for this week.
Have you ever watched Gattaca? The movie takes place in the future where parents have the option of selecting preferred genetic traits in their children. Society is split into two types of people: the genetically engineered, and the natural born. The problem is that the genetically engineered people have a superior place in society, and the natural born are devalued. The main character in the movie has vast capabilities, but he’s disregarded because he was considered physically weak, and expected to die at an early age. Yet, he goes against all odds, and overcomes society’s predestination for him. Although Gattaca is a movie, it reveals some truth that may be possible in the future.
The article addresses some good points about genetic engineering where bad traits such as disease are weeded out. I think taking a preventive approach to curing disease is the best way to stop something harmful from occurring. But regarding genetic material, there seems to be a thin line between preventive and manipulative genetic outcomes. I do not oppose preventing disease or physical dysfunctions, I am concerned about how this option may disturb a "designed" child's natural growth. Parents will be very tempted to give what they perceive is the best future for their offspring. Making a baby could be like suping a vehicle. As long as your have the basic components, you can add, enhance, and remove the parts to please your taste. All parents want the best for their children, but they might confuse their children’s interest with their own interest.
We must not forget that how a child develops is both a process of Nature and Nurture. Just because the genetics have been modified, doesn’t mean the child will be perfect. Perhaps even modifying the genetics will interfere with how the child will be nurtured because there is an expectation that the child will be perfect. This may inadvertently cause parents to become more careless. This may also have a psychological effect on the child, because he/she may perceive himself as being perfect. In Gattaca, one of the supporting characters was genetically engineered to be a perfect specimen. Growing up “perfect” had a deep impact on his expectations and perception of himself. Throughout the movie, you wonder why he is disturbed. It isn't until the end that you realize he became mentally unstable after he won second place in a swimming competition instead of first.
I’ve made quite a few references to a fictional movie, but I can’t help but see that it could become a reality. We must remember too not take good intentions too far and mutating it into something else. There are physical, social, and psychological risks in genetic engineering.
Babies of Their Own
Submitted by Abby on 9 December, 2005 - 12:58am. Med-Tech Blog(In response to “Science Makes Sex Obsolete”)
Out of all the different sections in this article, such as “Designer Babies” and “Ovarian Transplant”, the section “Manufactured Eggs and Sperm” captured my attention the most, particularly the prospect of homosexual men being able to have babies with genetic make-up from both men. For mammals, nature’s rules indicate that a female’s egg and a male’s sperm fuse together and exchange genetic material to eventually create an embryo, which grows into an individual. Dr. Gianpiero Palermo of Cornell University announced in 2001 that he and his team had used cloning techniques to create artificial haploid eggs. Regular cells have two sets of chromosomes, or are diploid. In order to receive a sperm’s chromosomes, the cell must go through haploidization, where half a cell’s chromosomes are ejected. The team of scientists removed the nucleus of a donor eggs and inserted an adult body cell, which fused to the egg. Once fusion occurred, the egg was fertilized with sperm. Although “fifty-two percent of the reconstituted eggs fertilized normally”, others did not develop as they should have. To fix this, the team inserting embryonic stem cells into the donor eggs instead of inserting the adult body cells. By doing this, the haploidization of the cells occurred and became sperm, creating embryos. Now imagine this process being used for gay men to make their very own babies; one man’s cell could be turned into an egg, which can then be fertilized by his partner’s sperm. The four main ways gay men can have children is through adoption, co-parenting, donor insemination, and surrogacy. It seems as if men will be able to have babies of their own (not that the babies obtained in the above mentioned ways were not the men’s) with both partner’s genes. Although this issue will undoubtedly be a controversial one and a much-heated topic, allowing homosexuals to create offspring is a beautiful thing (life in itself is beautiful), and I would very much give my support. I understand that there are thousands of children up for adoption in which homosexuals in relationships could adopt, but I think homosexuals should truly consider their options, especially if science makes it possible for them to have their genetically made babies.
Breaking Barriers
Submitted by Jenny Jiang on 8 December, 2005 - 11:38pm. Med-Tech Blog(In response to "Science Makes Sex Obsolete". Also fulfills the 500-word requirement.)
Lisa and Jack Nash were both carriers of a gene mutation that resulted their first daughter, Molly, to be born with a rare and fatal genetic disorder called Fanconi Anemia. In order to continue living, Molly needed a bone marrow transplant but it was impossible for the Nash's to find a match.
I'd Like an Order of Liver
Submitted by Abby on 8 December, 2005 - 11:22pm. Med-Tech Blog(In response to “Printing Organs on Demand”)
“Wow!” This one word basically sums up all my thoughts about the organ printing issue introduced to be in the article. I had no clue there was a research group funded by the National Science Foundation (amongst others) that grew organs. Of course, this research is still in its preliminary stages. Tissue engineering technology has been around and promises to solve the organ transplantation crisis, but the assembly of vascularized 3D soft organs remains a big challenge…until now. Growing organs and other tissue using the previous tissue engineering technology seemed to scientists to be taking to long; organ printing is computer-aided, jet-based 3D Tissue Engineering of living human organs and offers a possible solution to the slow growing organs by enabling rapid assembling of tissues and organs. Organ printing involves three sequential steps: pre-processing or development of ‘blueprints’ for organs; processing or actual organ printing; and post-processing or organ conditioning and accelerated organ maturation. Although, organ printing is still in its infancy, its prospects look good in solving the organ transplantation crisis. But how far will this go? The idea of printing organs, creating organs, seems to be a controversial one. If tissue can be grown, if organs can be grown, what else is can be grown? Could brains eventually be grown? If so, how soon or later will the technology be capable of growing man? Growing man (or woman) is a scary concept, but we can’t throw the possibility of it from happening completely out the window; at least, not with the ever-advancing technologies. To bring up another idea, if organ printing does work, could foods such as meats like steak cuts, eventually be printed?
U.S. Lacking Funds for Stem Cell Research
Submitted by Abby on 2 December, 2005 - 4:47pm. Med-Tech Blog(In response to "Egg Ethics Spark Stem-Cell Rift")
So, one of South Korea's most beloved scientists is shunned by a leading American stem cell scientist. Gerald Schatten ended a 20-month long collaboration with Hwang Woo-suk due to Hwang's use of "unethical practices". In 2003, Schatten toured Dr. Hwang's South Korean laboratory, and it was at this visit that Dr. Hwang pulled Schatten aside to tell him that some of his lab workers extracted stem cells from a successfully cloned human embryo. Schatten then assisted Dr. Hwang and his group of scientists in publishing the breakthrough information (with the breakthrough information being the success of cloning a human embryo from a human egg and then extracting stem cell from the cloned human embryo) and announced the collaboration to help Dr. Hwang's World Stem Cell Hub in collecting eggs. The next thing you know, Schatten calls the whole thing off.
A Flawless Plan?
Submitted by Jenny Jiang on 2 December, 2005 - 4:37pm. Med-Tech Blog(In response to “Clock Ticking on Vaccine Options”)
On October 31, the Bush administration proposed a $7.1 billion plan called the “National Strategy for Pandemic Influenza” to fight the potential pandemic avian flu. The key plan was to make an avian flu vaccine known as Tamiflu, for every American. Soon after the proposal was announced, analyst from talk shows, the newspapers, and academic institutions began to unfold some major flaws that underlie Bush’s agenda.
Pandemic on the Rise
Submitted by Abby on 30 November, 2005 - 12:13am. Med-Tech Blog(In response to “Clock Ticking on Vaccine Options”)
Sam Jaffe brings up a great but disturbing point. His take on the much needed vaccine preparation for a pandemic avian flu should not be heeded lightly. The disturbing aspect of his point, which he mentions in his article, is the government’s slow movement toward a vaccine for this ultimately deadly virus.
Ethics Dilemma
Submitted by thanhtran on 29 November, 2005 - 9:45pm. Med-Tech BlogNote: This will fulfill my 500 word requirement
In response to "Egg Ethics Spark Stem-Cell Rift"
After reading the November 14th article from Wired.com, I thought cloning researchers such as Scott Kaplan and Gerald Schatten wouldn’t suddenly stop cooperating with The World Stem Cell Hub foundation simply because of some rumors. I sorted through some online news, and found out that Hwang Woo-suk of The World Stem Cell Hub has recently “divulged everything.”
The article basically reports that Hwang made a public apology, and admitted that two female scientists in his lab had donated their eggs to the research. The Health Ministry said that this wasn’t in violation of the ethics guidelines because the eggs were voluntarily donated. The procedure is arduous, and thousands of eggs are required for the cloning projects, but there are few donors. It seems that a South Korean doctor has mentioned that there was compensation to the donors. A chairman of the board of Mizmedi Hospital also admitted he paid the donors, but added that Hwang didn’t know anything of the matter.
The donors were subordinates to Hwang and also a part of the team of scientists working on the project. The issue of having the eggs donated by the scientists is that there may be the chance of it stemming from coercion. Throughout the articles I’ve been able to find, there has been no mention of the donors themselves, though this issue directly involves them. They know what really happened, and whether or not they donated their eggs for the sake of science, obligation to their work or superiors, or money.
Then there’s the problem of ethics again. Some people think that there is a clear ethical line that people involved in the research of embryonic cloning should not contribute their eggs paid or unpaid for fear of obligation as a subordinate to their career or supervisor. There are also those that believe it’s okay if it is freely donated.
What a controversial issue. This will not stop me from expressing my personal opinion on the matter; I have welcomed expectations of heated phone calls aimed at my radio show. My personal opinion is that the ethics issue should not focus on whether the donors were employed under The World Stem Cell Hub, but whether or not they were paid for their eggs, coerced, or threatened in any way. I have to be honest and say that as long as the female scientists donated their eggs without any payment, it should graciously be accepted. As mentioned above (though without proof yet), there is the possibility that the donors were compensated. I approve that the donors should be compensated because they physically risk their bodies and health for the procedure. I do not think a simple “thank you” is enough gratitude. I do not think a large sum of money is appropriate to give to a “volunteer,” but some form of thanks or recognition should be provided. The female scientists should be allowed to make personal choices without the fear of it being misinterpreted as not being their personal choice. The ethics dilemma focuses on their involvement as being an entirely bad thing. The ethical issue is pertinent to keep scientists from corrupting, but is the idea of a female scientist donating or even sacrificing for the sake of her interest in the progress of finding a cure for diseases really not a possibility?
Presymptomatic Testing
Submitted by Jenny Jiang on 18 November, 2005 - 5:57pm. Med-Tech Blog(In response to both articles)
In recent years, the possibility and sensitivity of genetic screening have increased dramatically by technological advances introduced by top researchers and scientists. Such technology includes the Genelex’s GeneMedRx drug-interaction test, a new service in which one can “customize” his/her combination of medication according to his/her genetic makeup. Another new tool is the HIV test that promises not only portability but also faster result, features that current HIV testing lacks. Currently, biotech companies are applying similar technology for screenings of heart diseases, cancer, and other diseases.
Following the Rx Course
Submitted by Abby on 17 November, 2005 - 11:38pm. Med-Tech Blog(In response to "Drug Cocktail, No Hangover")
Genelex's GeneMedRx drug-interaction testing service is a terrific way to prevent thousands of perhaps preventable deaths a year. By simply giving a sample of blood, one’s genetic makeup is determined, which then allows for a patient's ability to metabolize certain types of drugs to be determined. This will then prevent them death due to ill drug interactions. Of course, such testing as that of the Genelex’s costs money; $800 for a bundle of tests, in fact. Right now, individuals have to dish out the money from their own pockets (we all know that healthcare doesn’t come cheap, especially for those who really can’t afford it, such as the elderly living off their monthly social security or those on welfare…but that’s a different story and we’ll save it for another time), which shouldn’t be the case. Prescribing these drugs that bring harm to a patient shouldn’t be done in the first place. Doctors should screen their patients to begin with, meaning the test fee should be paid by the doctors or refunded back to the their patients. After all, doctors are healthcare providers (to use the term loosely) and they should maximally care for their patients and be aware of the possible and individualized side effects their patients may experience. But, it’s still not necessarily the doctors’ fault for fringing harm to a patient’s health. Pharmaceutical companies are so advent about pushing their medicines that some go to the extent of giving free samples (a rather impressive advertising technique) to promote the drugs to physicians who then prescribe these to their patients to pick up at the pharmacy. The pharmaceutical companies should not market such drugs that have poor and harmful side effects. On top of that, however, drugs should be put through years and years of trials before the Food and Drug Administration approves them. Why? Because, according to Genelex, “21.3% of the 548 most recently FDA approved medications were subsequently withdrawn from the market or given a black box warning” (visit Genelex’s Adverse Drug Reactions Facts for more information). So, as much as I promote DNA testing, much more should be done to prevent adverse reactions from even occurring in the first place.
Diagnostic Technology
Submitted by thanhtran on 17 November, 2005 - 9:39pm. Med-Tech BlogAfter reading “Handheld Puts AIDS Fight in Field,” I thought, “Finally!”
I know I’m not a bioengineer or anything, but it seems to me if the world has been using portable pregnancy tests for thirty years, I expected portable disease detectors to appear sooner or later.
Many scientists have been working to make diagnostic technology cheaper and more portable. The diagnostic process can take days or weeks, first getting a bodily fluid sample, then shipping it off, have it examined in a lab, and finally have your results delivered by phone or mail. Imagine how exhausting this process can be in a developing country, such as Africa, where people travel from an obscure place to get tested, and sometimes never know what they’re diagnosed with simply because they can’t be located later. The highlight of the article on HIV diagnosing is that the card can be reprogrammed to detect other diseases and cancers. I think it’s not uncommon for a person to get tested, and never receive their results. The “blissful” ignorance of not knowing if one is sick is not only harmful to one’s self, but to others as well. The sooner someone learns he/she is sick, the sooner we can attempt to cure it, prevent it from spreading, or at least buy some time for a longer life. I’m quite optimistic and looking forward to how this instrument will change diagnostic procedures and people’s personal lives.
An article I found from the University of Houston is more informative than the one from Wired.com:
What I would like to know that the articles from Wired.com and U.H. didn’t address is how accurate the tests are. It only stressed the convenience of the new technology.
Genelex, Genetic Counseling, and Perceived Risk
Submitted by thanhtran on 17 November, 2005 - 2:15pm. Med-Tech BlogWouldn’t it be wonderful to know things ahead before you make a mistake? Genelex has developed a lab process in which they can identify your genetic profile. This profile is then used to guide your decisions in medication intake so that your nutrition and drugs(s) will not cancel each other out—or worse, harm or kill you. The concept is similar to genetic counseling where two people’s genes can be examined to consider the possibility of a disease being passed onto their offspring. This preventive strategy sounds quite useful, and what I’m interested in is its psychological effects when conducted on different cases.
And interesting article from Washington Post discusses Genelex’s genetic profiling:
Think of how this test can affect our psyche and perception of risk when we know what exactly our chances of being harmed are. For instance, the article mentions smoking. Smokers overall have a 3X greater risk than nonsmokers of getting bladder cancer. Using genetic profiling, one can determine precisely what the chances of getting bladder cancer are. Those two genes that are “normal copies had a risk that was only two times greater. Those with one good gene and one bad one had a risk four times greater. And those with two bad genes had a risk seven times greater.”
This knowledge will no doubt have an effect on a person once they find out which “smoker’s” gene they have. It is likely that when a person knows their chances of getting a disease is significantly lower than every else, he/she may be more likely to take the risk and continue smoking or using whatever drug. A person who is already smoking knows that he/she is risking getting a disease. If he/she discovers that the chances of getting a disease is higher, one can say that since the risk is perceived as even higher now, the person is likely to quit the habit. I think the opposite; the person will continue with the habit because that person was willing to risk getting a disease in the first place, so their perceived risk wouldn’t really change.
On a note about the prescription process, the doctor is the one who prescribes the drugs, so why is it that doctors don’t already take it as their responsibility to make sure the patient isn’t harmed by the drug? It’s a little ridiculous to me that after we get a drug, then do we, the ones who aren’t medicine experts, seek out more medical aid and fork over the extra money to make sure the drug will fit well with other drugs and foods.
Life is a Right
Submitted by Abby on 17 November, 2005 - 2:09pm. Med-Tech Blog(In response to "Handheld Puts AIDS Fight in Field")
Kudos goes out to the team of scientists at Harvard and the University of Texas at Austin who developed the CD4 sensor system. Obviously, there are other HIV diagnostic instruments available. One of these is the Uni-Gold Recombigen HIV test that requires just one drop of whole blood, plasma, or serum to detect HIV(visit: US FDA approves 10 minute HIV test). What makes the CD4 different is the reprogramming of the chip to detect other diseases such as those of the heart as well as cancers. Now, this is all good in that it will detect HIV cheaply, but the question is for whom will it be cheap? It appears as if the cost for development along with all the reprogramming chips is going to be a tidy sum of money, and of course, the reproduction of this technology is going to cost money as well. And if this is going to be shipped to the sub-Saharan Africa, how much are these quick and easy tests going to cost the people getting tested or the testing programs in which that partake? Uni-Gold’s test costs approximately $10 U.S. dollars, which is by far too much when you take into account the total population that will be tested. With HIV and AIDS being a worldly and deadly epidemic, shouldn’t hands be lent (money saved) to save lives? Isn’t life a right? Now, let’s just say that the price of the CD4 is pretty cheap (at least less than Uni-Gold’s $10 price); what is going to be done for treatment? Treatment is still too costly for the general African population, not to say the least for the world population. Again, life is a right, and we should do all that can be done to promote it, even if it means putting less money in our pockets Mr. Scientist and Ms. LabNow Technician.
Introduction
Submitted by Jenny Jiang on 15 November, 2005 - 3:01pm. Med-Tech BlogMy name is Linda Nagasaki. I am currently a professor in the extremely under funded Department of Communication at University of Wisconsin. My work focuses mainly on gender, race and technology.
Amendment
Submitted by thanhtran on 10 November, 2005 - 2:35pm. Med-Tech BlogAmendment for the Med-Tech Blog
- Blog entries are at least 250 words per article
- 2 blog entries on certain articles are submitted twice a week
- Articles are chosen on Tuesdays and will be announced on the blog
- Thursdays' times are used for blogging (but not required)
- Blog entries are due Fridays
- Blog responses are due Sunday nights, and are at least 100 words per response
- Two blog responses are required per week
- It would be appreciated if the classroom instructor participates, advise, and make suggestions on the issues at hand
G. Robenstein
Submitted by thanhtran on 8 November, 2005 - 2:49pm. Med-Tech BlogHello, my name is Gracie Robenstein. My short bright blonde hair is now almost white from the years of experience as a woman, wife, and mother. I am a busy woman in my fifties, but not tired yet. I am a university researcher and a radio personality on an A.M. talk show which I host between 8 until 10 on weeknights. Under the pen name, Dr. Mom, I offer parenting advice and discuss issues about children and families that are raised through my research, emails, and phone calls I receive on my show. I am an expert on child psychology, beginning from the time I was 16 and assisted my mom who was a pediatric nurse in a local children’s hospital. Since then, my interest in children bloomed, and I first walked in my mother’s footsteps as a nurse, and eventually went back to school to earn a doctorate in Child Psychology.
My education and experience is the backbone of my strength as an advisor, but my age is a different issue. It is hard keeping up with the times since technology is changing fast, and this has a profound impact on human behavior and culture. Even though I have been working as a child psychologist for 15 years, in the radio job for over 10 years, and addressed thousands of issues, I still enjoy it. I try my best to connect to my audience on a personal and empathetic as well as professional level without revealing too much about my personal identity. The issues discussed on my talk show are sensitive, and though I try my best to be unbiased, sometimes I receive negative mail and discouraging phone calls for my liberal ideas about parenting and familial relationships.
Introduction
Submitted by Abby on 8 November, 2005 - 2:43pm. Med-Tech BlogAllow me to introduce myself. I am my own mother’s daughter. I have been blessed; my mother’s greatest traits have surfaced in me and now make up a portion of my greatest traits and could possibly even define my character. This fact, in itself, is proof that I am my own mother’s daughter. Not many can say they are as lucky as I am lucky. Good judgment and morals are hard to come by these days. My mother is a woman who has good judgment and a strong set of morals and values. She may seem to be a physically frail woman, but this has not hindered her moral strength. Some may call her old fashioned, as do many of those from the most recent generation who have forgotten the essence of morality and values, but nonetheless, I am lucky enough to have been blessed with the very traits that allow me to sleep comfortably at night knowing that I am my own mother’s daughter.
I do not like the fact that the line between good and bad, between right and wrong, and between moral and immoral has been so skewed that much of the population finds it is too difficult to make a judgment call. I guess that is why some turn to others for help, for advice when the call needs to be made by someone who encompasses the knowledge of the distinction. I am one of those persons.
